Curr Opin Neurobiol. 2002 Oct;12(5):516-22.
PTEN function in mammalian cell size regulation.

Backman S, Stambolic V, Mak T.

Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Canada. sbackman@uhnres.utoronto.edu

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation. Publication Types: * Review * Review, Tutorial PMID: 12367630