Curr Opin Neurobiol. 2002 Oct;12(5):516-22.
PTEN function in mammalian cell size regulation.

Backman S, Stambolic V, Mak T.

Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Canada.

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation. Publication Types: * Review * Review, Tutorial PMID: 12367630